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Nicotine’s promotion of aneurysm rupture requires α7*-nicotinic acetylcholine receptors (α7*-nAChR) expressed on smooth muscle cells. A, α7f/f SM22Cre+ treated with nicotine and α7f/f treated with nicotine. B, α7f/f LysMCre+ treated with nicotine and α7f/f treated with nicotine. C, α7f/f Tie2Cre+ treated with nicotine and α7f/f treated with nicotine. *P < 0.01 vs α7f/f + Nicotine.
