Table 1. Morphological findings and tumor classification of patients investigated.
| Males (N = 39) | Females (N = 23) | |
|---|---|---|
| Isolated CCH, N (proportion) | 15 (0.38) | 8 (0.35) |
| Neoplastic | 8 (0.53) | 4 (0.5) |
| Physiological (diffuse or nodular) | 7 (0.47) | 4 (0.5) |
| MTC, N (proportion) * | 24 (0.62) | 15 (0.65) |
| pT1a | 14 (0.58) | 9 (0.60) |
| pT1b | 4 (0.17) | 4 (0.27) |
| pT2 | 2 (0.08) | 2 (0.13) |
| pT3 | 4 (0.17) | 0 |
| pT4 | 0 | 0 |
| Multifocality, N (proportion) | 5 (0.21) | 1 (0.07) |
| Tumor diameter, (mm) | 6 (1 - 19) (absolute range: 1 - 87) | 9 (4 - 15) (absolute range: 1 - 21) |
| Concomitant CCH, N (proportion) | 18 (0.75) | 5 (0.33) |
| Neoplastic | 12 (0.67) | 3 (0.60) |
| Physiological | 6 (0.33) | 2(0.40) |
| Meta, N (proportion) | 8 (0.33) | 3 (0.20) |
| N1a | 2 (0.25) | 2 (0.67) |
| N1b | 6 (0.75) | 1 (0.33) |
| Dist Meta, N (proportion) | 3 (0.13) liver; N = 2 liver + lung + bone; N = 2 |
0 |
| RET mutation, N (proportion) | 1 (0.04) exon 13, codon 791; N = 1 |
4 (0.27) exon 13/codon 791; N = 1 exon 13/768; N = 3 |
| CCH - C-cell hyperplasia. MTC - medullary thyroid cancer. *Local tumor stage according to UICC 2010 - pT1a ≤ 10 mm; pT1b = 11 - 20 mm; pT2 = 21 - 40 mm; pT3 > 40 mm or any size with with extrathyroidal extension; pT4 = moderately advanced or very advanced disease. Meta - lymph node metastasis: N1a - central lymph node metastasis, N1b - lateral lymph node metastasis. Dist Meta - distant metastasis. RET mutation - mutation in the rearranged during transfection (RET) proto-oncogene, found after diagnosis of MTC. | ||