. 2018 Oct 15;28(3):030710. doi: 10.11613/BM.2018.030710

Table 3. Prediction of C-cell hyperplasia and medullary thyroid cancer in males and females.

Male patients (N = 39)
Stimulation by	Group	Prediction of morphology		N (proportion)	Combination of			Definitive diagnosis	N (proportion)	pT1a^*	pT1b^*	pT2^*	pT3^*	pT4^*		N1	M1
Stimulation by	Group	Prediction of morphology		N (proportion)	bCT (pg/mL)	sCT (pg/mL)		Definitive diagnosis	N (proportion)	N (proportion)
Pg	1	CCH or MTC		23 (0.59)	≥ 8 ≤ 43	≤ 470		CCH	15 (0.65)
	1	CCH or MTC		23 (0.59)	≥ 8 ≤ 43	≤ 470		MTC	8 (0.35)	8 (1.0)
	2	MTC		16 (0.41)	≥ 8 ≤ 43	> 470		MTC	16 (1.0)	6 (0.38)	4 (0.25)	2 (0.13)	4 (0.25)		0	5 (0.31)	3 (0.19)
	2	MTC		16 (0.41)	> 43	≤ 470		MTC	16 (1.0)	6 (0.38)	4 (0.25)	2 (0.13)	4 (0.25)		0	5 (0.31)	3 (0.19)
Ca	2	MTC		13 (0.33)	≥ 8 ≤ 43	> 1500		MTC	13 (1.0)	3 (0.23)	4 (0.31)	2 (0.15)	4 (0.31)		0	5 (0.38)	3 (0.23)
	2	MTC		13 (0.33)	> 43	≤ 1500		MTC	13 (1.0)	3 (0.23)	4 (0.31)	2 (0.15)	4 (0.31)		0	5 (0.38)	3 (0.23)
	1	CCH or MTC		26 (0.67)	≥ 8 ≤ 43	≤ 1500		MTC	11 (0.42)	11 (1.0)
	1	CCH or MTC		26 (0.67)	≥ 8 ≤ 43	≤ 1500		CCH	15 (0.58)
Female patients (N = 23)
Pg	1	CCH or MTC	11 (0.48)		≥ 6 ≤ 24		≤ 200	CCH	8 (0.73)
	1	CCH or MTC	11 (0.48)		≥ 6 ≤ 24		≤ 200	MTC	3 (0.27)	3 (1.0)						1 (0.33)
	2	MTC	12 (0.52)		≥ 6 ≤ 24		> 200	MTC	12 (1.0)	6 (0.50)	4 (0.33)	2 (0.17)	0		0	2 (0.17)
	2	MTC	12 (0.52)		> 24		≤ 200	MTC	12 (1.0)	6 (0.50)	4 (0.33)	2 (0.17)	0		0	2 (0.17)
Ca	2	MTC	11 (0.48)		≥ 6 ≤ 24		> 780	MTC	11 (1.0)	5 (0.45)	4 (0.36)	2 (0.18)	0		0	2 (0.18)
	2	MTC	11 (0.48)		> 24		≤ 780	MTC	11 (1.0)	5 (0.45)	4 (0.36)	2 (0.18)	0		0	2 (0.18)
	1	CCH or MTC	12 (0.52)		≥ 6 ≤ 24		≤ 780	MTC	4 (0.33)	4 (1.0)						1 (0.09)
	1	CCH or MTC	12 (0.52)		≥ 6 ≤ 24		≤ 780	CCH	8 (0.66)
bCT - basal calcitonin. sCT - stimulated calcitonin. ^*Local tumor classification according to UICC 2010 - pT1a ≤ 10mm; pT1b = 11 - 20 mm; pT2 = 21- 40 mm; pT3 > 40 mm or any size with with extrathyroidal extension; pT4 = moderately advanced or very advanced disease. N1 - lymph node metastasis. M1 - distant metastasis. Pg - pentagastrin. Ca - calcium. Group 1 - C-cell disease not predictable (CCH or MTC possible). Group 2 - MTC predicted in all patients. CCH - C-cell hyperplasia, MTC - medullary thyroid cancer. Gray zone represents correctly predicted MTC with pentagastrin stimulation in 16 (0.67) of 24 finally diagnosed MTCs compared to 13 (0.54) after calcium stimulation (Fisher’s exact test; P = 0.556) for male patients, and in 12 (0.80) of 15 finally diagnosed MTCs compared to 11 (0.73) patients after calcium stimulation (Fisher’s exact test: P = 1.000) for female patients.