Table 2. Neutrophil gelatinase-associated lipocalin diagnostic accuracy calculated by two consecutive tests and referred to AKI stage.
|
Sensitivity (95% CI) |
Specificity (95% CI) |
NPV | |
|---|---|---|---|
| Stage AKI 1, 2 and 3 | |||
| ΔNGAL post ≥ 100 | 86% (76 - 92) | 51% (40 - 62) | 87% |
| *ΔNGAL post ≥ 100 and ΔsCr > 14% | 79% (68 - 87) | 83% (72 - 90) | 88% |
| Stage AKI 2 and 3 | |||
| ΔNGAL post ≥ 100 | 93% (84 - 97) | 43% (32 - 55) | 97% |
| *ΔNGAL post ≥ 100 and ΔsCr > 14% | 86% (76 - 92) | 70% (59 - 80) | 96% |
| AKI - acute kidney injury. NPV - negative predictive value. NGAL - neutrophil gelatinase-associated lipocalin. sCrea - serum creatinine. *Δ represents increase of biomarker concentration and was obtained as difference between biomarker concentration after and before surgery. | |||