Table 1.

Odds ratios and 95% confidence intervals for osteosarcoma risk associated with polygenic height scores

Height trait(s) modeled by polygenic score	SNPs in polygenic score(s)	OR (95% CI)a	P-value(s)b
Birth	5	1.07 (0.99–1.17)	0.11
Childhood	6	1.10 (1.01–1.20)	0.023
Adult	416	1.10 (1.01–1.19)	0.027
Adultreducedc	410	1.09 (1.00–1.19)	0.048
Adultreducedc & Childhood	410 & 6	1.09 (1.00–1.19) & 1.10 (1.01–1.20)	0.048 & 0.023

^aOR represents the osteosarcoma risk associated with one standard deviation increase in polygenic height score, corresponding to approximately 1.7 cm of adult height, 0.5 cm of childhood height, and 0.14 cm of birth length, estimated by multiplying the standard deviation of each polygenic height score (calculated using beta values of standardized height from prior GWAS regression analyses) by the standard deviation of population height in centimeters averaged between men and women aged 20 years and over for adult height, between boys aged 12 and girls aged 10 for childhood height, and between male and female infants from birth to two months for birth length, reported from the National Health and Nutrition Examination Survey data on the U.S. population in 2007–2010

^bP-values are unadjusted for multiple testing

^cAdult polygenic height score excluding SNPs that are in linkage disequilibrium with childhood height SNPs