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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Cancer Res. 2018 Aug 30;78(21):6282–6296. doi: 10.1158/0008-5472.CAN-18-0894

Figure 4.

Figure 4.

Analysis of mitotic phenotypes induced by MST-312 and Pt-ttpy treatment of HT1080 cells. Cells in different stages of mitosis were stained with antibodies against phosphorylated HistoneH3 (Ser10) –a mitotic marker (in red) and α-tubulin (in green). A-B, and E-F, DMSO-treated control cells. C-D, MST-312-treated cells show chromosome alignment defects. Red arrows point at uncongressed chromosomes. G-H, Chromatin bridges appear in both MST-312- and Pt-ttpy-treated cells. Red/blue arrows point at chromatin bridges.