. Author manuscript; available in PMC: 2019 Jan 5.

Published in final edited form as: Lab Invest. 2018 Jul 5;98(11):1449–1464. doi: 10.1038/s41374-018-0093-9

Table 1.

Evaluation of liver and body weight, and liver to body weight ratio, serum chemistry and levels of TGF-β1 in serum and cholangiocyte supernatant.

Parameters	C57	FVB	C57/FVB	SR^−/−	Mdr2^−/−	SR^−/−/Mdr2^−/−

Liver weight (gm)	1.7±0.3	1.6±0.1	1.6±0.1	1.6±0.4	2.6±0.1^*	2.2±0.1
Liver weight (gm)	n=34	n=13	n=12	n=15	n=15	n=11

Body weight (gm)	26.0±0.5	30.0±0.5	31.1±1.4	32.0 ± 1.5	30.6±0.4	30.6±1.1
Body weight (gm)	n=34	n=13	n=12	n=15	n=15	n=11

Liver to body weight ratio (%)	6.4±0.2	5.4±0.1	5.2±0.3	5.7±0.2	8.5±0.3^*	7.2±0.1^#
Liver to body weight ratio (%)	n=34	n=13	n=12	n=15	n=15	n=11

SGPT (Units/L)	326.3±32.6	131.3±16.6	124.3±11.9	321.5±68.4	1153.5±55.6^*	794.5±21.9^#
SGPT (Units/L)	n=4	n=4	n=4	n=4	n=4	n=4

SGOT (Units/L)	485.0±53.5	431.3±25.9	570±89.8	427.5±174.3	1710.3±216.8^*	893.8±102.8^#
SGOT (Units/L)	n=4	n=4	n=4	n=4	n=4	n=4

ALP (Units/L)	<45±5.0	<50±0.0	<56.5±6.5	<47.25±2.8	342.5±27.2^*	237.0±17.5^#
ALP (Units/L)	n=4	n=4	n=4	n=4	n=4	n=4

TGF-β1 levels in serum (pg/ml)	276.9±36.3	78.7±4.7	118.5±10.2	69.4±0.8	7970.7±304.8^*	1617.5±132.3^#
TGF-β1 levels in serum (pg/ml)	n=4	n=4	n=4	n=4	n=4	n=4

TGF-β1 levels in cholangiocyte supernatant (ng/ml)	4.0±0.5	0.5±0.3	1.3±0.5	24.7±1.2	764.5±30.0^*	216.9±10.6^#
TGF-β1 levels in cholangiocyte supernatant (ng/ml)	n=4	n=4	n=4	n=4	n=4	n=4

P<0.05 vs. FVB mice;

P<0.05 vs. Mdr2^−/− mice.