Table 2.
Clinical characteristics of each melanoma, overall clinical dysplastic nevus (DN) status, and age at last status in the 24 pediatric melanoma patients.
| Patient No. | Mel No. | Age at Mel Diagnosis, years | Thickness, mm | Study Period | Precursor Lesion | Patient Clinical DN Status |
Age at last status, years |
|---|---|---|---|---|---|---|---|
| 1 | 1 | 16 | 2.1 | Retrospective | No | Yes | 47 |
| 2 | 34 | 2.85 | At Exam | Yes/not DN | |||
| 2 | 1 | 13 | MIS | Retrospective | Yes/DN | Yes | 49 |
| 2 | 13 | MIS | Retrospective | Yes/DN | |||
| 3 | 16 | 0.43 | Prospective | Yes/DN | |||
| 4 | 16 | MIS | Prospective | Yes/DN | |||
| 5 | 16 | MIS | Prospective | Yes/DN | |||
| 6 | 16 | MIS | Prospective | Yes/DN | |||
| 7 | 16 | 0.35 | Prospective | Yes/DN | |||
| 8 | 18 | MIS | Prospective | Yes/DN | |||
| 9 | 18 | MIS | Prospective | Yes/DN | |||
| 10 | 21 | Microinvasive | Prospective | Yes/DN | |||
| 11 | 42 | MIS | Prospective | Yes/DN | |||
| 12 | 45 | MIS | Prospective | Clinical nevusb | |||
| 13 | 46 | 0.28 | Prospective | Yes/DN | |||
| 3 | 1 | 19 | 0.72 | Prospective | Yes/DN | Yes | 45 |
| 2 | 19 | 0.94 | Prospective | No | |||
| 4 | 1 | 13 | MIS | Prospective | Yes/DN | Yes | 36 |
| 2 | 36 | MIS | Prospective | Yes/DN | |||
| 5 | 1 | 14 | Unknown | Retrospective | Yes/DN | Yes | 63 |
| 2 | 24 | 0.4 | Retrospective | Yes/DN | |||
| 3 | 24 | 0.22 | Retrospective | No | |||
| 4 | 26 | 0.41 | Prospective | Yes/DN | |||
| 5 | 26 | Microinvasive | Prospective | Yes/DN | |||
| 6 | 27 | MIS | Prospective | Yes/DN | |||
| 7 | 31 | 0.25 | Prospective | Yes/DN | |||
| 8 | 31 | 0.39 | Prospective | Yes/DN | |||
| 9 | 32 | 0.38 | Prospective | Yes/DN | |||
| 10 | 33 | 0.35 | Prospective | No | |||
| 11 | 35 | Microinvasive | Prospective | No | |||
| 12 | 37 | 0.5 | Prospective | No | |||
| 13 | 41 | 0.45 | Prospective | Yes/not DN | |||
| 14 | 41 | 0.55 | Prospective | Yes/DN | |||
| 15 | 41 | 0.33 | Prospective | No | |||
| 16 | 42 | MIS | Prospective | No | |||
| 17 | 48 | 0.42 | Prospective | No | |||
| 18 | 48 | MIS | Prospective | Yes/DN | |||
| 19 | 48 | MIS | Prospective | No | |||
| 20 | 55 | MIS | Prospective | Yes/DN | |||
| 21 | 55 | MIS | Prospective | Unknown | |||
| 22 | 56 | MIS | Prospective | Yes/DN | |||
| 23 | 62 | 0.84 | Prospective | Clinical nevusb | |||
| 6 | 1 | 19 | 1.5 | Retrospectivea | Yes/not DN | Unknown (Not Examined) | 21 |
| 7 | 1 | 19 | 2.42 | Retrospective | Yes/DN | Yes | 25 |
| 2 | 22 | 1 | Retrospective | Yes/DN | |||
| 3 | 22 | 0.4 | Retrospective | Yes/DN | |||
| 4 | 23 | 0.54 | Retrospective | Yes/DN | |||
| 8 | 1 | 17 | Unknown | Retrospective | Unknown | Unknown (Not Examined) | 20 |
| 9 | 1 | 12 | 0.88 | Retrospective | Yes/not DN | Yes | 25 |
| 10 | 1 | 18 | Microinvasive | Retrospective | Yes/DN | Yes | 60 |
| 2 | 21 | Microinvasive | Retrospective | Yes/DN | |||
| 3 | 21 | 0.88 | Retrospective | Yes/DN | |||
| 4 | 21 | 0.15 | Retrospective | Yes/DN | |||
| 5 | 22 | Microinvasive | Retrospective | Yes/not DN | |||
| 6 | 23 | 0.56 | Retrospective | Yes/DN | |||
| 7 | 24 | Microinvasive | Prospective | Yes/DN | |||
| 8 | 24 | MIS | Prospective | No | |||
| 9 | 26 | MIS | Prospective | Yes/not DN | |||
| 10 | 26 | 0.59 | Prospective | Yes/DN | |||
| 11 | 27 | MIS | Prospective | No | |||
| 12 | 28 | MIS | Prospective | No | |||
| 13 | 28 | MIS | Prospective | Yes/DN | |||
| 14 | 28 | Microinvasive | Prospective | Yes/DN | |||
| 15 | 29 | 0.33 | Prospective | Yes/DN indeterminate |
|||
| 16 | 29 | Microinvasive | Prospective | No | |||
| 17 | 29 | Microinvasive | Prospective | No | |||
| 18 | 29 | MIS | Prospective | Yes/not DN | |||
| 19 | 35 | MIS | Prospective | No | |||
| 20 | 36 | Unknown | Prospective | Unknown | |||
| 21 | 38 | 0.33 | Prospective | Yes/DN | |||
| 22 | 42 | MIS | Prospective | Clinical nevusb | |||
| 23 | 45 | MIS | Prospective | Unknown | |||
| 24 | 47 | 0.24 | Prospective | Yes/DN | |||
| 25 | 48 | MIS | Prospective | Yes/DN | |||
| 26 | 50 | 0.4 | Prospective | Yes/DN indeterminate |
|||
| 27 | 51 | MIS | Prospective | Unknown | |||
| 28 | 52 | MIS | Prospective | Unknown | |||
| 29 | 52 | 0.25 | Prospective | Unknown | |||
| 30 | 54 | 0.5 | Prospective | Unknown | |||
| 31 | 56 | 0.34 | Prospective | Clinical nevusb | |||
| 32 | 57 | 0.2 | Prospective | Clinical nevusb | |||
| 11 | 1 | 19 | 1.65 | Prospective | Yes/DN | Yes | 51 |
| 2 | 30 | MIS | Prospective | Yes/not DN | |||
| 3 | 35 | MIS | Prospective | Unknown | |||
| 4 | 40 | MIS | Prospective | Yes/DN | |||
| 5 | 42 | MIS | Prospective | Yes/DN | |||
| 6 | 46 | 0.4 | Prospective | Unknown | |||
| 7 | 49 | MIS | Prospective | Unknown | |||
| 12 | 1 | 17 | 0.3 | Prospective | No | Yes | 26 |
| 2 | 18 | 0.35 | Prospective | Yes/DN | |||
| 3 | 19 | 0.33 | Prospective | Yes/DN | |||
| 13 | 1 | 16 | 0.7 | Prospective | No | Yes | 20 |
| 2 | 18 | 0.55 | Prospective | Yes/DN indeterminate |
|||
| 14 | 1 | 17 | 1.66 | Retrospective | No | Yes | 27 |
| 2 | 20 | MIS | Prospective | Yes/DN | |||
| 15 | 1 | 17 | MIS | Retrospective | No | Yes | 44 |
| 2 | 39 | 0.53 | Prospective | Yes/not DN | |||
| 16 | 1 | 14 | 0.52 | Retrospective | Yes/DN | Yes | 25 |
| 2 | 14 | 0.46 | Retrospective | Unknown | |||
| 3 | 16 | 0.37 | Retrospective | Yes/DN | |||
| 4 | 16 | 0.4 | Retrospective | Yes/DN | |||
| 5 | 16 | 0.32 | Retrospective | Yes/DN | |||
| 6 | 20 | 2.4 | Retrospective | Yes/DN | |||
| 7 | 21 | 1 | Retrospective | Yes/DN | |||
| 8 | 21 | MIS | Retrospective | Unknown | |||
| 17 | 1 | 9 | 0.34 | Prospective | Yes/DN | Yes | 30 |
| 2 | 10 | 0.49 | Prospective | Yes/not DN | |||
| 3 | 30 | MIS | Prospective | Clinical nevusb | |||
| 18 | 1 | 11 | 0.47 | Prospective | No | Yes | 23 |
| 19 | 1 | 13 | MIS | Prospective | No | Yes | 22 |
| 20 | 1 | 18 | 6.5 | Prospective | Yes/DN | Yes | 32 |
| 21 | 1 | 18 | MIS | Prospective | No | Indeterminate | 33 |
| 22 | 1 | 15 | 0.32 | Retrospectivea | Yes/DN | Yes | 31 |
| 2 | 15 | 0.64 | Retrospective | No | |||
| 3 | 15 | MIS | Retrospective | Yes/not DN | |||
| 4 | 16 | 0.43 | Retrospective | Yes/not DN | |||
| 5 | 16 | 0.45 | Retrospective | Yes/not DN | |||
| 23 | 1 | 13 | Unknown | Retrospectivea | Unknown | Unknown (Not Examined) | 39 |
| 24 | 1 | 17 | 0.6 | Retrospectivea | Yes/DN | Yes | 44 |
Abbreviations: No., Number; Mel, melanoma; mm, millimeters; DN, dysplastic nevus; MIS, melanoma-in-situ
a
Patient was a proband, i.e., one of the melanoma patients who led to ascertainment of family
b
Clinical nevus means that on a previous exam, or by history, a nevus was present but it was not detected in pathology report