Table 3.
Regions showing significant grey matter loss in MS patients (p<0.01, FWE-corrected at cluster level).
| Comparison | Regions | Side | BA | MNI coordinates (x,y,z) | T value | Cluster size | p-value |
|---|---|---|---|---|---|---|---|
| AAs<CTRLs | Uncus | L | 6 | 26, −8, −50 | 6.32 | 16403 | < 0.001 |
| CBL | R | - | 16, −58, −58 | 5.99 | 5591 | < 0.001 | |
| CBL | L | - | −32, −54, −22 | 5.37 | 1019 | 0.001 | |
| ITG | R | 37 | 48, −54, −4 | 4.91 | 1193 | < 0.001 | |
| PCL | R | 3 | 14, −34, 60 | 4.67 | 1130 | < 0.001 | |
| CAs<CTRLs | Thalamus | R | - | 8, −8, 12 | 4.95 | 730 | 0.003 |
| AAs<CAs | CBL | R | - | 12, −74, −50 | 6.37 | 1649 | < 0.001 |
| Uncus/FG | R | 38 | 24, −8, −46 | 6.30 | 1400 | < 0.001 | |
| Uncus/FG | L | 38 | −24, −10, −48 | 5.82 | 1263 | < 0.001 | |
| SFG | L | 6 | −20, 22, 60 | 5.74 | 1065 | < 0.001 | |
| CBL | L | - | −12, −66, −60 | 5.68 | 1397 | < 0.001 | |
| LG | L | 18 | 0, −68, 6 | 4.95 | 720 | 0.004 |
Abbreviations: AAs=African Americans; BA=Brodmann area; CAs=Caucasians; CBL=cerebellum; CTRLs=controls; FG=fusiform gyrus; ITG=inferior temporal gyrus; L=left; LG=lingual gyrus; PCL=paracentral lobule; R=right; SFG=superior frontal gyrus.