TABLE 2.
Factors associated with reports of fatigue and high fatigue distress (univariate analysis)
| All Reports (n=920) | Fatigue Reports (n=425) | |||||
|---|---|---|---|---|---|---|
| No Fatigue (n=495) |
Fatigue (n=425) |
p* | Low Distress* (n=67) |
High Distress* (n=358) |
p* | |
| Demographic characteristics | ||||||
| Site of care | 0.31 | 0.53 | ||||
| Site 1, n (%) | 105 (61) | 67 (39) | 15 (22) | 52 (78) | ||
| Site 2, n (%) | 257 (51) | 248 (49) | 38 (15) | 210 (85) | ||
| Site 3, n (%) | 133 (55) | 110 (45) | 14 (13) | 96 (87) | ||
| Female, n (%) | 215 (49) | 222 (51) | 0.32 | 24 (11) | 198 (89) | 0.03 |
| Age at enrollment, median years (IQR) | 11.7 (6.7-16.7) | 14.7 (8.7-17.2) | 0.05 | 10.4 (6.5-16.4) | 15.4 (8.7-17.6) | 0.05 |
| White non-Hispanic, n (%) | 441 (54) | 372 (46) | 0.55 | 61(16) | 311 (84) | 0.34 |
| Disease characteristics | ||||||
| Diagnosis | 0.80 | 0.72 | ||||
| Hematologic malignancy, n (%) | 165 (54) | 141 (46) | 25 (18) | 116 (82) | ||
| Solid tumor, n (%) | 277 (52) | 256 (48) | 36 (14) | 220 (86) | ||
| Brain tumor, n (%) | 53 (65) | 28 (35) | 6 (21) | 22 (78) | ||
| Months from diagnosis to enrollment, median (IQR) | 25 (15-50.6) | 30.6 (20-50.6) | 0.14 | 26.3 (17.9-54.1) | 30.7 (20.5-50.4) | 0.96 |
| Disease status active/progressive | 323 (55) | 267 (45) | 0.63 | 48 (18) | 219 (82) | 0.12 |
| Months since last disease progression, median (IQR) | 6.1 (3.7-9.5) | 5.6 (3.2-9.4) | 0.38 | 5.4 (3.2-9.4) | 6.1 (3.4-8.7) | 0.28 |
| Treatment (past 10 days) | ||||||
| Cancer-directed treatment (any) | 256 (53) | 231 (47) | 0.12 | 39 (17) | 192 (83) | 0.42 |
| Type of cancer treatment | ||||||
| Chemotherapy | 245 (53) | 214 (47) | 0.23 | 38 (18) | 176 (82) | 0.24 |
| Procedure | 36 (44) | 47 (56) | 0.07 | 13 (28) | 34 (72) | 0.05 |
| Surgery | 3 (27) | 8 (73) | 0.21 | 1 (12) | 7 (88) | 0.21 |
| Radiation therapy SCT conditioning |
14 (36) | 25 (64) | 0.13 | 0 | 25 (100) | 0.13 |
| Opioid therapy | 56 (40) | 85 (60) | 0.02 | 6 (7) | 79 (93) | 0.07 |
| Hemoglobin (g/dl), mean (SD) | 10.9 (1.7) | 10.7 (1.9) | <0.01 | 10.7 (2.4) | 10.7 (1.9) | 0.94 |
| Physical Symptoms:High Distress** | ||||||
| Anorexia | 67 (29) | 168 (71) | <.001 | 17 (10) | 151 (90) | <0.01 |
| Nausea | 63(28) | 160 (72) | <0.001 | 6 (4) | 154 (96) | <0.001 |
| Cough | 74 (46) | 86 (54) | 0.06 | 4 (5) | 82 (95) | <0.01 |
| Diarrhea | 72 (37) | 123 (63) | <0.001 | 15 (12) | 108 (88) | 0.49 |
| Pain | 155 (43) | 205 (57) | <0.01 | 14 (7) | 191 (93) | <0.001 |
| Difficulty sleeping | 62 (31) | 140 (69) | <0.001 | 15 (11) | 125 (89) | 0.27 |
| Psychological Symptoms:High Distress** | ||||||
| Sadness | 60 (38) | 100 (62) | <0.001 | 10 (10) | 90 (90) | 0.1 |
| Irritability | 104 (42) | 141 (58) | <0.001 | 20 (14) | 121 (86) | 0.52 |
| Worry | 63 (39) | 99 (61) | <0.01 | 5 (5) | 94 (95) | <0.01 |
*
Adjusted for intervention arm and respondent clustering (patient level clustering)
**
Symptom distress scores: High distress defined as a score ≥44 for PQ-MSAS 7-12, and ≥33 for PQ-MSAS-13-18 and PQ-MSAS-proxy-full.
Abbreviations: IQR, inter-quartile range; SD, standard deviation