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. Author manuscript; available in PMC: 2019 Feb 24.
Published in final edited form as: Lab Invest. 2018 Aug 24;98(11):1465–1477. doi: 10.1038/s41374-018-0101-0

Figure 1.

Figure 1

(A) Mdr2−/− mice fed BAC displayed increased portal area damage including inflammation, necrosis and increased ductular reaction compared to WT mice. (B) Total bile acids (TBAs) were increased in serum in Mdr2−/− mice fed BAC compared to WT and feeding with UDCA decreased TBAs in serum. (C) H&E in human biopsies reveal increased inflammation and necrosis in PSC patients compared to control, which are reduced in PSC patients treated with UDCA. (D) Serum ALT levels are increased in patients with PSC compared to control and ALT levels are decreased in two patients treated with UDCA. Data are expressed as mean ± SEM of at least 8 experiments for TBA. *p<0.05 versus WT mice; #p<0.05 versus Mdr2−/− mice fed BAC. Images are 20× magnification.