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. Author manuscript; available in PMC: 2019 Feb 24.
Published in final edited form as: Lab Invest. 2018 Aug 24;98(11):1465–1477. doi: 10.1038/s41374-018-0101-0

Figure 4.

Figure 4

(A) Bile duct mass and (B) Ki-67 were evaluated in liver sections from WT, Mdr2−/− mice + BAC and Mdr2−/− mice fed UDCA. We found that bile duct mass (CK-19 staining, red arrows) and Ki-67 increased in Mdr2−/− mice fed BAC compared to WT mice, whereas in Mdr2−/− mice fed UDCA, there was decreased bile duct mass (red arrows) and a lower number of proliferating cholangiocytes (red arrows). Data has been semi-quantified and are expressed as mean ± SEM of at least 10 experiments. *p<0.05 versus WT mice; #p<0.05 versus Mdr2−/− mice fed BAC diet. Images are 20× magnification (inserts are 40× magnification).