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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Curr Opin Cell Biol. 2018 Jun 8;54:98–105. doi: 10.1016/j.ceb.2018.05.012

Figure 2. Branching morphogenesis is regulated by mechanical forces imposed by its surrounding microenvironment.

Figure 2

A. Airway branching in the mouse lung is accompanied by localized smooth muscle differentiation at bifurcating tips [34] and stratification of the epithelium during domain branching B. The branching rate of the murine airway epithelium can be modulated using a microfluidic transmural pressure device [37]