Figure 1:

(A) Experimental paradigm (B – D) EEG seizure burden, number of ictal events (counts), and ictal durations (sec) in PTZ, +PB, +PB+BTN treatment groups. Seizure burden post-PTZ remained stable over the 3h-recording period when no PB treatment was administered. PB (25 mg/kg; IP) was efficacious as an anti-seizure agent (grey bars) to suppress PTZ-induced seizures. BTN, administered as an adjunct to PB, failed to improve PB-efficacy (white bars), and led to a loss of PB-suppressed seizures in treatment group administered. (E – G) Corresponding % suppression of seizure burden, % suppression of ictal events, and % suppression of ictal duration. EEG sample size: n=13 males, n=13 females. Within groups: *P < 0.05, **P < 0.01, ***P ≤ 0.001, two-way ANOVA with Bonferroni post-hoc correlations. Between groups: #P < 0.05, ##P < 0.01, ###P ≤ 0.001, one-way ANOVA with Bonferroni post-hoc correlations.