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Mechanistic differences in ischemia and PTZ model (A) Significant model-specific differences in KCC2 expression, but no model-specific differences in NKCC1 expression. Sample size: n=12 for Ischemia-induced NKCC1 expression, n=6 for PTZ-induced NKCC1 expression. One-way ANOVA with Bonferroni post-hoc correlations: *P < 0.05, **P < 0.01, ***P ≤ 0.001. Additional information: (Kang et al., 2015a) (B) Schematic of model specific changes in KCC2 and TrkB pathway activation.
