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. Author manuscript; available in PMC: 2019 Jan 30.
Published in final edited form as: Nat Struct Mol Biol. 2018 Jul 30;25(8):698–704. doi: 10.1038/s41594-018-0093-x

Figure 1 |. Structure of the αvβ8 integrin in extended-closed conformation.

Figure 1 |

a, Cryo-EM structure of αvβ8–8B8–68 complex at a global 6.4Å resolution. The axial and head-domain dimensions are shown. b, The atomic model shown in ribbon format and fit into the EM density. Names of individual domains are shown. The headpiece consists of the αv-head, thigh, β8 βI, hybrid and Psi-EGF1 domains. c, Close up of the headpiece, which is resolved to 4.8Å through focused alignment. d, Close up of the β8 headpiece showing the glycan attached to N191 as well as the two bulky sidechains H200 and F195. e, Close up of the αv headpiece showing the glycan attached to N44 and the bulky side chain F88. The color code is: αv-green; β8-blue; Fab 68-orange; Fab 8B8-yellow.