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. Author manuscript; available in PMC: 2019 Jan 30.
Published in final edited form as: Nat Struct Mol Biol. 2018 Jul 30;25(8):698–704. doi: 10.1038/s41594-018-0093-x

Figure 3 |. The αv-leg stabilizes integrin extension of the αvβ3 integrin.

Figure 3 |

a–c, Schematic of the wild type (WT) αvβ3 (a), αvβ3-lower leg truncation (αvβ3 HP) (b), and αvc-cβ3 (c) ectodomains and nomenclature with representative ns-EM class averages of bent, en face extended-closed and extended-open conformations (b, e, h), and a pie chart representing percentages of each conformation (c, f, i). Below each 2D class average is the percentage of particles belonging to that conformation and the number of particles in parentheses.