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. 2018 Nov 2;8:16274. doi: 10.1038/s41598-018-34625-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Retinoid contents (sum of 13-cis-4-oxo and all-trans-4-oxo-RA) in honeybees exposed to increasing concentrations of IMI (A) and THM (B). Boxes (5–8 pools of 10 bees, except 4 pools for 12 ng/100 ml) extend from 25th to 75th percentile; line is the median and whiskers show the largest to smallest observed values. ^Δp < 0.05 Jonkheere-Terpstra trend test.