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. 2018 Nov 2;8:16243. doi: 10.1038/s41598-018-34693-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Images of one selected region each from two TMA sample cores: one from an ILC core top left) and another from a BAT core (top right). SPPARC images for selected regions with stromal collagen within tumor for ILC and stromal collagen in benign tissue adjacent to tumor for BAT are shown. The corresponding depolarization and linear DOP parameter spatial maps are also shown (along with inset text showing mean and standard deviation over all pixels in the image) revealing a lower depolarization and higher linear degree-of-polarization for stromal collagen within tumor.