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. 2018 Nov 2;9:4600. doi: 10.1038/s41467-018-06833-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Myh10 deficiency causes emphysema-like phenotypes. a H&E staining of wild-type (n = 10) and Gli1-Myh10^cKO (n = 8) P7 lungs. Quantification of alveolar space in wild-type and Gli1-Myh10^cKO P7 lungs. b Immunostaining for α-SMA in wild-type (n = 10) and Gli1-Myh10^cKO (n = 8) P7 lungs. Arrows point to secondary septae. Quantification of secondary septae length in wild-type and Gli1-Myh10^cKO P7 lungs. c Immunostaining for Tropoelastin in wild-type (n = 10) and Gli1-Myh10^cKO (n = 8) P7 lungs. Arrowheads point to truncated elastin fibers. d H&E staining and morphometric analysis of alveolar space in wild-type (n = 8) and Gli1-Myh10^cKO (n = 6) adult lungs. Arrowheads point to macrophages. e Immunostaining for MMP2, tropoelastin, and fibronectin in wild-type (n = 8) and Gli1-Myh10^cKO (n = 6) adult lungs. Arrowheads point to truncated elastin fibers. Error bars are means ± s.e.m. ***P < 0.001, ****P < 0.0001, two-tailed Student’s t-test. Scale bars: 50 μm (a, d), 30 μm (b, c (left), e (left, right)), 15 μm (c (right), e (middle))