Table 1.
Summary of clinical laboratory evaluation for infertile males.
| ID# | Age | Sperm count | Semen volume (mL) | pH | T*, (3–12 ng/mL) | PRL**, (units vary) | FSH, (1.5–12.4 IU/L) | LH, (1.8–8.6 IU/L) | Scrotal ultrasound testing | Karyotype | AZFs del | ADGRG2 Mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| III.3 | 42 | 0 | 0.9 | 7.0 | 1.9 | 10 ng/mL (0–20 ng/mL) | 4.3 | 3.1 | bilateral mild hydro cele, left varicocele, 2.3 × 3.1 cm (right), 2.1 × 3 cm (left) | Normal 46, XY male | Norm | c.2440C > T |
| III.5 | 29 | 0 | 1 | 7.0 | 2.1 | NA | 6.5 | 5.8 | NA | NA | Norm | c.2440C > T |
| III.13 | 35 | 0 | 1.2 | 8.0 | 2.95 | 162 IU/L (0–425 uIU/mL) | 9.07 | 7.55 | Hypotrophy, 1.3 × 1.6 cm (right), 1.2 × 1.3 cm (left) | Normal 46, XY male | Norm | c.2440C > T |
Semen analysis of III.3, III.5, and III.13 males indicated low semen volume (<1.5 mL) and slightly acidic semen pH (<7.2) in III.3 and III.5 males, both characteristic of obstructive azoospermia. Due to absent sperm, other testing, such as motility and morphology, was not performed. Abnormal values are indicated in bold. T: testosterone, PRL: prolactin, FSH: follicle stimulating hormone, LH: luteinizing hormone, AZFs: Y chromosome regions AZFa, AZFb, and AZFc. Results indicated as “NA” were not collected. “Norm” designates normal findings. T*- Testosterone levels were collected outside of the recommended timeframe (7am-10am). PRL** - different units used by different laboratories.