Figure 9.
Effect of HD5 on EtOH and colitis-induced upregulation of plasma cytokines. Adult mice were subjected to DSS-induced colitis three times with 15-day intervals, followed by 30-day recovery from third colitis. During the intervals and recovery period, mice were fed a liquid diet with EtOH (EF) or isocaloric maltodextrin (PF) and with or without HD5 supplementation. TNFα (A), IL-1β (B) and IL-6 (C) levels in plasma were measured by ELISA. Plasma samples from mice in different groups were also analyzed for lipopolysaccharide (LPS) levels (D). Values in all panels are mean ± sem (n = 6). Asterisks indicate the values that are significantly (p < 0.05) different from corresponding PF values, and the symbol Δ indicates values that are different from corresponding values for DSS + EF group.