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. 2018 Nov 2;9:4583. doi: 10.1038/s41467-018-06949-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PDGFR inhibitors have limited efficacy against Y288C mutation. MCF10A cells expressing PDGFRA mutants were treated with DMSO or 2.44nM-10 μM of a PDGFR inhibitors (Imatinib, Nilotinib, Sunitinib, and Crenolanib), b PI3K/mTOR inhibitor (GSK2126458), MEK inhibitor (GSK1120212B), or STAT3 ASO (AZD9150) for 3 days. Each treatment was performed in triplicate and cell viability is presented as mean ± SD. The IC50 was calculated with Graphpad Prism 6