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. 2018 Nov 2;8:16238. doi: 10.1038/s41598-018-33233-0

Figure 1.

Figure 1

Long-term effects of early HO-1 induction in Mdr2−/− mice. (A) Hepatic Ho-1 expression over time of Mdr2−/− treated with either HO-1 inducer CoPP [5 mg/kg] or PBS twice a week for nine consecutive weeks (week 5–14), compared to 5-week-old WT mice (n ≥ 4). (B) Body weight gain in relation to initial weight over time of two representative experiments with mice described in (A) (n ≥ 7). (C) Activity of plasma alanine aminotransferase (ALT) over time of mice described in (A) (n ≥ 6). (D) Plasma level of albumin of mice described in (A) (n ≥ 6). The dotted lines indicate physiological range of plasma ALT (17–77 U/L) and ALB (24–48 g/L) of WT animals. (E) Hepatic CD4+ T cells, CD8+ T cells, and NKT cells of 14- and 65-week-old animals. Data are expressed as means ± SEM. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Asterisks in red depict significance of difference between 14- and 65-week old PBS treated Mdr2−/− mice.