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. 2018 Nov 2;9:4589. doi: 10.1038/s41467-018-07042-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Epithelial Stat3 deletion induces sex-associated differences in K-ras mutant tumor burden. Lung surface tumor number (left panel) and histopathologic appearance (40× magnification, scale bar = 100 μm) of the lung in female (red circles, n = 12–14) (a) and male (blue squares, n = 12–15) (c) CC-LR (middle panel) and LR/Stat3^Δ/Δ (right panel) mice at the age of 14 weeks. Quantitative analysis (left panel) and representative lung photomicrographs (20× magnification, scale bar = 50 μm) of positive tumor cells for Ki-67 in female (n = 11–14) (b) and male (n = 12–14) (d) CC-LR (middle panel) and LR/Stat3^Δ/Δ (right panel) mice at the age of 14 weeks. (Data represent means ± standard error of mean (SEM); ^****P < 0.0001; ^***P < 0.001; ^**P < 0.005 using two-tailed t-test, experimental replicate # 3–4)