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. 2018 Nov 2;9:4604. doi: 10.1038/s41467-018-07033-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Proposed model of simple sugar preference regulation by neuronal SIRT1. Ingestion of simple sugar promotes secretion of FGF21 from the liver. The hepatokine FGF21 acts as an endocrine signal to Oxt neurons and promotes Oxt transcription (AKT signalling) and neuronal activation (ERK signalling). Oxt suppresses simple sugar preference by acting on OXTR. SIRT1 promotes FGF21 sensitivity in Oxt neurons and stimulates Oxt transcription through NRF2, thereby potentiating the negative feedback regulation of simple sugar preference through FGF21 and Oxt