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. 2018 Nov 2;9:4605. doi: 10.1038/s41467-018-06899-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Rules of chemical and electrical connectivity between PV⁺ interneurons. a Left, light micrograph of a biocytin-labeled PV⁺ interneuron–PV⁺ interneuron pair. Right, unitary IPSCs, with individual synaptic responses (gray) and average trace (red, 15 traces) in the same pair. GCL, granule cell layer; IML, inner molecular layer. b PV⁺ interneuron–PV⁺ interneuron chemical connection probability (left) and IPSC peak amplitude (right) plotted versus intersomatic distance. Connection probability data points were fit with a sigmoidal function, IPSC amplitude data were analyzed by linear regression. Maximal connection probability was 58.1%, and space constant was 141 μm. c Electrical coupling between two PV⁺ interneurons. Voltage changes in the pre- and postsynaptic cell caused by the injections of long polarizing current pulses (left, + 200 pA; right, −200 pA; 200 ms) in one of the coupled cells. d PV⁺ interneuron–PV⁺ interneuron electrical connection probability (left) and coupling coefficient (right) plotted versus intersomatic distance. Maximal connection probability was 77.3%, and space constant was 146 μm. The coupling coefficient (CC) was calculated as the mean ratio of steady-state voltages (V₂/V₁, V₁/V₂) during application of current pulses in one of the cells (cell 1 and cell 2, respectively)