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Structures of l-kynurenine (left) and kynurenic acid (right). l-kynurenines such as quinolinic acid are excitatory, but kynurenic acid, produced from l-kynurenine by the action of kynurenine aminotransferase (KCAT1), is an inhibitor of NMDA iGluRs and α7 nAChRs. I3AA inhibits KCAT1, blocking production of both molecules by this pathway.
