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. 2018 Oct 11;10(10):410. doi: 10.3390/toxins10100410

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MnTBAP reverses the long lasting reduction of mitochondrial electron transport chain protein transcription caused by transient exposure to urea. HAEC were exposed to 20 mM urea for 48 h, or to 20 mM urea for 48 h followed by two days of subsequent incubation in media alone, , with or without MnTBAP. The mRNA expression was measured by Real time PCR: (A) ND1; (B) ND4; (C) ND4L; and (D) cytochrome b. Data are the mean ± S.E. from five independent experiments. * p < 0.05 compared to cells treated in the same conditions but not exposed to urea, # p < 0.05 cells not treated with the inhibitor compared to cells treated with MnTBAP.

Inline graphic — MnTBAP reverses the long lasting reduction of mitochondrial electron transport chain protein transcription caused by transient exposure to urea. HAEC were exposed to 20 mM urea for 48 h, or to 20 mM urea for 48 h followed by two days of subsequent incubation in media alone, , with or without MnTBAP. The mRNA expression was measured by Real time PCR: (A) ND1; (B) ND4; (C) ND4L; and (D) cytochrome b. Data are the mean ± S.E. from five independent experiments. * p < 0.05 compared to cells treated in the same conditions but not exposed to urea, # p < 0.05 cells not treated with the inhibitor compared to cells treated with MnTBAP.