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. 2018 Oct 11;10(10):410. doi: 10.3390/toxins10100410

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MnTBAP reverses the persistent reduction in transcription of mitochondrial fusion and increase in fission proteins caused by transient exposure to urea. HAEC were exposed to 20 mM urea for 48 h or to 20 mM urea for 48 h followed by two days of subsequent incubation in media alone, with or without MnTBAP . The mRNA expression was measured by Real time PCR: (A) Fis1; (B) Mfn1; (C) Mfn2; and (D) OPA1. Data are the mean ± S.E. from five independent experiments. * p < 0.05 compared to cells treated in the same conditions but not exposed to urea, # p < 0.05 cells not treated with the inhibitor compared to cells treated with MnTBAP.

Inline graphic — MnTBAP reverses the persistent reduction in transcription of mitochondrial fusion and increase in fission proteins caused by transient exposure to urea. HAEC were exposed to 20 mM urea for 48 h or to 20 mM urea for 48 h followed by two days of subsequent incubation in media alone, with or without MnTBAP . The mRNA expression was measured by Real time PCR: (A) Fis1; (B) Mfn1; (C) Mfn2; and (D) OPA1. Data are the mean ± S.E. from five independent experiments. * p < 0.05 compared to cells treated in the same conditions but not exposed to urea, # p < 0.05 cells not treated with the inhibitor compared to cells treated with MnTBAP.