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. 2018 Sep 26;8(10):762. doi: 10.3390/nano8100762

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The integration of SERS nanoprobes and a microfluidic dielectrophoresis (DEP) device for rapid detection of single bacterium. (a) Schematic presentation of using antibody-conjugated nanoaggregate-embedded beads (NAEBs) as SERS nanoprobes for specific detection of bacteria. (b) Photograph of the microfluidic DEP device and close-up view of central capturing area with four the quadrupole electrodes. (c) The distribution of electric field of four microelectrodes in the microchannel. (d) Schematic illustration of the DEP-SERS configuration. Reproduced with permission [93]. Copyright WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2014.