Fig. 1.

CSF sTREM2 in patients hospitalized by a hip fracture. a A fragment of the microglial receptor TREM2 and sTREM2, released after ectodomain shedding, drains to the CSF. Sampling and time line of hip fracture patients admitted to the hospital where some of them developed delirium. b CSF sTREM2 level did not discriminate patients not developing delirium from patients developing delirium during hospitalization for an acute hip fracture surgery (p = 0.25, n = 54, n = 65). c Stratification and separate analyses of patients with and without pre-existing dementia showed significantly higher CSF sTREM2 level in delirium of patients without pre-existing dementia (p = 0.046, n = 15, n = 44). Dementia patients with and without delirium had a similar CSF sTREM2 level (p = 0.94, n = 10, n = 50). Two tailed p values were obtained by Mann-Whitney test, while larger and smaller lines represent the median and interquartile range respectively. CSF: cerebrospinal fluid, sTREM2: soluble TREM2