Fig. 2.

Human ependymogenesis proceeds posterior to anterior along lateral ventricle wall during fetal-to-postnatal development and exhibits characteristic pinwheel organization. (A,B) Human fetal (A) and postnatal/adult (B) ependymal cell development was examined at 21 gw, 28 gw, 34 gw, 10 day, 6 months, 7 months, 8 years and 39 years (n=1). Representative schematics of microscope images of a 3391.90 µm² (fetal) or 13,567.59 µm² (postnatal) area of the lateral ventricle frontal horn are indicated by red squares on 2D ventricular surface projections (black). Pie charts below schematics indicate percentage of radial glia, immature ependymal cells, V-SVZ stem cells and mature ependymal cells along anterior, middle and posterior regions. Scale bars: 1 cm in A (2D ventricle wall renderings); 5 cm in B (2D ventricle wall renderings); 20 µm in A,B (tissue sections).