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Summary of ventral body wall closure in wild-type and Six4−/−;Six5−/− embryos. Schematic of the normal ventral body wall closure (left) and large middle-type omphalocele formation (right) during the E10.5-E13.5 period. See text for details. The number under each mouse stage indicates the Carnegie stage (CS) of the human embryo corresponding to the mouse development stage. L, liver; MEPCs, mesothelial progenitor cells.
