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. 2018 Oct 11;28(12):4440–4453. doi: 10.1093/cercor/bhy256

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Cortical clustering by trajectory. (A) shows 6 clusters found by k-means clustering. (B) The clusters are well-differentiated when considered in a 3D space formed by the milestone markers of Figure 6: the age of peak grey matter volume, the age at onset of grey matter volume decline, and the age at which the volume loss is a maximum. (C) the mean trajectory for each cluster is shown, with the shaded region indicating a 95% bootstrap confidence interval.