Figure 4:

Topiramate (TPM) prolongs RED duration in a concentration-dependent manner. A) Representative traces of REDs recorded before (baseline) and in the presence of 100 µM TPM. B) Time courses for 100 µM TPM’s effects of RED duration (B1, green), frequency (B2, blue), and amplitude (B3, red). Dashed-line boxes from 20 to 40 minutes represent the duration of TPM exposure. Data points represent mean ± SEM for RED parameters in 1-minute bins. C) Concentration-dependent effects of TPM on RED duration (green), frequency (blue), and amplitude (red). Bars represent mean ± SEM of N slices (see Table 1) and * = p<0.05, ** = p<0.01, *** = p<0.001. D) Concentration-response curves fit to data from panel C for TPM’s effects on RED duration (green), frequency (blue), and amplitude (red).