Table 4.
Body and organ weights of rats subjected to subacute toxicity assessment of the hydroethanolic extracts of E. floribundus and A. indica.
Groups | Body weight (g) ± SD | ||||
---|---|---|---|---|---|
Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | |
(A) Rats treated with HEEF | |||||
Control | 123.3±9.1 | 127.8±8.8 | 131.8±9.2 | 136.8±8.8 | 143.5±9.5 |
60 mg/kg | 123.3 ± 10.3 | 126.3 ± 9.7 | 129.8 ± 9.6 | 131.8 ± 9.9 | 134.7±10.2 |
120 mg/kg | 123.3 ± 8.8 | 126.3 ± 9.0 | 129.7 ± 11.5 | 130.3 ± 8.2 | 133.0±7.7 |
240 mg/kg | 123.0 ± 13.1 | 126.4 ± 12.5 | 130.4 ± 8.6 | 132.0±10.7 | 134.2±10.6 |
| |||||
Groups | Organ weight (g) ± SD | ||||
Liver | Heart | Kidneys | Lungs | Spleen | |
| |||||
Control | 5.72 ± 0.66 | 0.62 ± 0.05 | 1.28 ± 0.13 | 1.16 ± 0.11 | 0.78 ± 0.19 |
60 mg/kg | 5.15 ± 0.58 | 0.60 ± 0.08 | 1.26 ± 0.13 | 1.51 ± 0.65 | 0.80 ± 0.14 |
120 mg/kg | 4.54 ± 1.46 | 0.54 ± 0.05 | 1.21 ± 0.09 | 1.39 ± 0.36 | 0.70 ± 0.15 |
240 mg/kg | 5.16 ± 0.32 | 0.52 ± 0.06 | 1.17 ± 0.04 | 1.40 ± 0.53 | 0.79 ± 0.19 |
| |||||
Groups | Body weight (g) ± SD | ||||
Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | |
| |||||
(B) Rats treated with HEAI | |||||
Control | 123.3 ± 9.11 | 127.8 ± 8.8 | 131.8 ± 9.2 | 136.8 ± 8.8 | 143.5 ± 9.5 |
75 mg/kg | 123.2 ± 15.3 | 127.0 ± 15.0 | 130.0 ± 14.5 | 136.6 ± 13.7 | 139.3± 4.6 |
150 mg/kg | 123.5 ± 10.2 | 128.0 ± 10.4 | 131.5 ± 9.4 | 136.0 ± 9.3 | 141.0±10.0 |
300 mg/kg | 122.7 ± 5.8 | 126.5 ± 5.5 | 130.0 ± 5.8 | 133.7 ± 6.3 | 137.2 ± 6.5 |
| |||||
Groups | Organ weight (g) ± SD | ||||
Liver | Heart | Kidneys | Lungs | Spleen | |
| |||||
Control | 5.72 ± 0.66 | 0.62 ± 0.05 | 1.28 ± 0.13 | 1.16 ± 0.11 | 0.78 ± 0.19 |
75 mg/kg | 5.65 ± 0.58 | 0.56 ± 0.06 | 1.25 ± 0.06 | 1.09 ± 0.11 | 0.81 ± 0.13 |
150 mg/kg | 5.93 ± 0.75 | 0.55 ± 0.05 | 1.33 ± 0.10 | 1.25 ± 0.37 | 0.74 ± 0.11 |
300 mg/kg | 5.08 ± 0.37 | 0.54 ± 0.04 | 1.22 ± 0.06 | 1.37 ± 0.25 | 0.86 ± 0.44 |
Mice (5) were administered with 60, 120, and 240mg/kg doses of HEEF, with 75, 150, and 300mg/kg doses of HEAI for 28 days, and mean body weight and organ weight were recorded before the treatment (day 0) and on days 7, 14, 21, and 28. The control group received 200 µL of distilled water.