Table 4.
Subjects | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|
Baseline Glucose | 117 | 173 | 323 | 321 | 113 | 110 | 254 | 261 | 137 | 386 | 457 |
Glucose after 1 month | 51 | 187 | 137 | 135 | 133 | 106 | – | 186 | 118 | 334 | 138 |
Glucose after 6 months | – | 164 | 167 | 158 | – | 107 | 97 | – | 143 | 116 | 77 |
HbA1c before | 8.6 | 10 | 8.8 | 14.6 | 6 | 6.5 | 12.1 | – | 6.3 | 8.6 | – |
HbA1c after 1 month | – | – | 5.2 | 7.5 | – | – | – | 11 | 6 | 6.7 | – |
HbA1c after 6 months | – | 7.1 | 6.2 | 7.6 | – | 6.3 | 6 | – | 5.7 | 7.6 | 5.7 |
Treatment before | Glyburide 5 mg TID Metformin 500 mg TID |
Metformin 500 mg TID Glyburide 5–5 – 2.5 |
Metformin / glyburide 500 mg/5 mg TID | Glyburide 5 mg BID Metformin 850 mg QD |
Metformin 500 mg QD | Metformin 500 mg QD | Glyburide 5 mg TID Metformin 850 TID |
Insulin Glargine 30 U QD Metformin 850 mg QD |
Metformin / glyburide 500 mg/5 mg half dose TID | NPH 45–0-20 Lispro 10–10-2 |
Glyburide 5 mg TID Metformin 850 mg TID |
Treatment after 6 months | Stayed the same | Metformin 500 mg TID Glyburide 5 mg TID |
Metformin /glyburide 500 mg/5 mg BID | Stayed the same | – | Stayed the same | NPH insulin 25 U QD Metformin 850 mg TID |
– | Stayed the same | NPH 25–0-20 Lispro 10–10-3 |
Suspended Metformin Glyburide 5 mg TID |
HbA1c Glycated hemoglobin, TID three times a day, BID two times a day, QD once a day, NPH neutral protamine Hagedorn