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. 2018 Nov 3;16:110. doi: 10.1186/s12958-018-0423-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A sketch of the T2D mouse model. (a) Body weight and (b) blood glucose were significantly increased (P<0.05) in T2D mice compared to the T2 DC group. (c) Glucose tolerance test (GTT) and (d) Insulin resistance test (ITT) at 16 weeks in T2D and T2 DC groups. T2D mice showed glucose intolerance and insulin resistance. After injection of STZ, at 20 weeks, glucose tolerance test (GTT) (e) and insulin resistance test (ITT) (f) are also seen in T2D mice. T2D mice showed persistent glucose intolerance and insulin resistance