Table 2.

Activation related to the hypothesized increase in dopamine across the COMT genotype and estradiol groups during the working memory load conditions of the N-back task including Talairach coordinates, cluster size, region description (Brodmann’s area, BA), t values, and corrected voxel-level p value. Increasing dopamine refers to a linear contrast across groups from high to low inferred dopamine: Met/Met high estradiol, Met/Val high estradiol, Val/Val high estradiol, Met/Met low estradiol, Met/Val low estradiol, and Val/Val low estradiol.

Contrast	Coordinates			Cluster Extent	Region Description	t value	p value
	x	y	z
Increasing Dopamine
Decreasing Activation	57	−4	31	155	Right precentral gyrus (BA 6)	−4.08	<.001