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HU treatment did not affect performance in the elevated plus maze. 6 to 8-month-old mice (A-B). NTG n =11, APP/PS1 n = 6, and APP/PS1 + HU n = 7. A) Time in the open arms (p = 0.901). B) Time in the closed arms and middle zone (p = 0.782). 10 to 13-month-old mice (C-D). NTG n = 9, NTG + HU n = 8, APP/PS1 n = 13, APP/PS1 + HU n = 13. C) Time in the open arms (p = 0.782). D) Time in the closed arms and middle zone (p = 0.147). Errors bars = SEM.
