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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Neurobiol Aging. 2018 Aug 29;72:121–133. doi: 10.1016/j.neurobiolaging.2018.08.021

Table 2. Summary of statistical analyses for Morris water maze probe trials.

Cohort 1: NTG n = 11, APP/PS1 n = 7, APP/PS1 + HU n = 7. Cohort 2: NTG n = 9, NTG + HU n = 8, APP/PS1 n = 13, APP/PS1 + HU n = 13.

Measurement Cohort Probe trial One-way ANOVA post-hoc p-value
 Percent time in
target quadrant
compared to chance
level (25%)		 1  24-hr  p = 0.007  pNTG < 0.01
 pAPP/PS1+HU< 0.05
1  48-hr  p = 0.023  pNTG < 0.05
 pAPP/PS1 + HU < 0.05
2  24-hr  p = 0.0003  pNTG < 0.001
 pNTG + HU < 0.01
2  48-hr  p = 0.034  pNTG + HU < 0.05
 pAPP/PS1 +HU < 0.05
 Percent time in
target quadrant
compared between
groups		 1  24-hr  p = 0.634
1  48-hr  p = 0.257
2  24-hr  p = 0.021  pNTG vs APP/PS1 < 0.01
2  48-hr  p = 0.353
 Percent time spent
in target quadrant
vs non-target
quadrants		 1  24-hr  pNTG = 0.001
 pAPP/PS1= 0.005

 pAPP/PS1+ HU= 0.001		  NTG: pUR vs UL pLR, LL < 0.001
 APP/PS1:pUR vs LR, LL < 0.01,
     p UR vs UL < 0.05
 APP/PS1+HU:pUR vs UL, LR, LL < 0.001
1  48-hr  pNTG = 0.001

 pAPP/PS1+ HU= 0.001		  NTG: pUR vs UL < 0.05, pLR, LL < 0.001

 APP/PS1+HU:pUR vs UL, LR, LL < 0.001

2  24-hr  pNTG = 0.0001
 pNTG + HU = 0.001

 pAPP/PS1+ HU= 0.001		  NTG: pUR vs UL pLR, LL < 0.001
 NTG + HU: pUR vs LR, LL <0.001,
     pUR vs UL < 0.01
 APP/PS1 + HU: pUR vs LR, LL < 0.001