Total	No KP (Q11)	Knee pain (Q11)	P-value
N	9506	5218	4288
Conditions
High cholesterol, n (%)	2634 (27.71)	1356 (26.00)	1278 (29.80)	<0.0001
Heart attack/angina, n (%)	604 (6.35)	287 (5.50)	317 (7.39)	0.0002
Hypertension, n (%)	2845 (29.93)	1400 (26.85)	1445 (33.70)	<0.0001
Diabetes, n (%)	899 (9.46)	423 (8.11)	476 (11.10)	<0.0001
Underactive/overactive thyroid, thyroiditis, n (%)	369 (3.88)	185 (3.54)	184 (4.29)	0.0608
Stroke, n (%)	271 (2.85)	142 (2.72)	129 (3.01)	0.4045
Multiple sclerosis, n (%)	18 (0.19)	10 (0.19)	8 (0.19)	0.9551
Irritable bowel syndrome, n (%)	963 (10.13)	427 (8.19)	536 (12.50)	<0.0001
Fibromyalgia, n (%)	246 (2.59)	68 (1.30)	178 (4.15)	<0.0001
Chronic fatigue syndrome, n (%)	133 (1.40)	55 (1.05)	78 (1.82)	0.0016
Chronic obstructive pulmonary disease (COPD), n (%)	103 (1.08)	54 (1.03)	49 (1.14)	0.6126
Asthma, n (%)	412 (4.33)	212 (4.06)	200 (4.66)	0.1514
Idiopathic pulmonary fibrosis, n (%)	3 (0.03)	3 (0.06)	0 (0.00)	0.1164
Liver cirrhosis, n (%)	6 (0.06)	4 (0.08)	2 (0.05)	0.5622
Hepatitis, n (%)	5 (0.05)	2 (0.04)	3 (0.07)	0.5031
Non-alcoholic fatty liver disease, n (%)	6 (0.06)	4 (0.08)	2 (0.05)	0.5622
Rheumatoid arthritis, n (%)	92 (0.97)	25 (0.48)	67 (1.56)	<0.0001
Ankylosing spondylitis, n (%)	19 (0.20)	3 (0.06)	16 (0.37)	0.0006
Lupus, n (%)	12 (0.13)	4 (0.08)	8 (0.19)	0.1331
Psoriatic arthritis, n (%)	17 (0.18)	4 (0.08)	13 (0.30)	0.0093
Systems affected
Cardiovascular disease, n (%)	4124 (43.38)	2105 (40.34)	2019 (47.08)	<0.0001
Endocrine disease, n (%)	1229 (12.93)	595 (11.40)	634 (14.79)	<0.0001
Non-restorative pain disorders, n (%)	1164 (12.24)	497 (9.52)	667 (15.56)	<0.0001
Lung disease, n (%)	497 (5.23)	263 (5.04)	234 (5.46)	0.3624
Liver disease, n (%)	17 (0.18)	10 (0.19)	7 (0.16)	0.7447
Chronic kidney disease/failure (CKD), n (%)	23 (0.24)	8 (0.15)	15 (0.35)	0.0523
Central nervous system disorders, n (%)	289 (3.04)	152 (2.91)	137 (3.19)	0.4246
Gout, n (%)	94 (0.99)	54 (1.03)	40 (0.93)	0.6175
Chronic rheumatic conditions, n (%)	138 (1.45)	35 (0.67)	103 (2.40)	<0.0001
Comorbidity count
N of comorbidities, mean (SD), n (%)	0.80 (0.85)	0.71 (0.81)	0.90 (0.90)	<0.0001
Any comorbidities, n (%)	5355 (56.33)	2740 (52.51)	2615 (60.98)	<0.0001
Any comorbidities ≥ 2, n (%)	1804 (18.98)	822 (15.75)	982 (22.90)	<0.0001
Any comorbidities ≥ 3, n (%)	367 (3.86)	137 (2.63)	230 (5.36)	<0.0001
Any comorbidities ≥ 4, n (%)	45 (0.47)	19 (0.36)	26 (0.61)	0.0868