Table 4.

SIRs and associated 95% CIs for gastrointestinal cancers in 71,189 patients with hypothyroidism diagnosed in Denmark in the period 1978–2013, stratified by time of follow-up.

Cancer site	Overall			<1 year			1–5 years			>5 years
	O	E	SIR	O	E	SIR	O	E	SIR	O	E	SIR
Overall	1608	1303	1.23 (1.17–1.30)	502	165	3.04 (2.78–3.32)	449	479	0.94 (0.85–1.03)	657	659	1.00 (0.92–1.08)
Esophagus	76	57	1.32 (1.04–1.66)	26	7	3.59 (2.35–5.27)	19	21	0.90 (0.54–1.41)	31	29	1.07 (0.73–1.51)
Stomach	148	99	1.49 (1.26–1.75)	43	14	3.12 (2.26–4.21)	44	39	1.14 (0.83–1.53)	61	47	1.30 (0.99–1.66)
Small intestines	20	16	1.25 (0.77–1.94)	9	2	4.60 (2.11–8.75)	5	6	0.86 (0.28–2.02)	5	8	0.73 (0.27–1.59)
Colon	731	591	1.24 (1.15–1.33)	230	74	3.12 (2.73–3.55)	215	215	1.00 (0.87–1.14)	286	302	0.95 (0.84–1.06)
Rectum	232	243	0.95 (0.83–1.08)	75	31	2.41 (1.90–3.03)	61	90	0.68 (0.52–0.87)	96	122	0.79 (0.64–0.96)
Anal canal	30	22	1.39 (0.94–1.99)	6	3	2.36 (0.86–5.13)	5	8	0.65 (0.21–1.51)	19	11	1.68 (1.01–2.63)
Liver	71	47	1.50 (1.17–1.89)	19	6	3.11 (1.87–4.86)	19	18	1.08 (0.65–1.69)	31	24	1.39 (0.96–1.96)
Gallbladder and biliary tract	72	48	1.49 (1.17–1.88)	19	6	3.01 (1.81–4.70)	20	18	1.11 (0.68–1.71)	33	24	1.38 (0.95–1.94)
Pancreas	228	179	1.27 (1.11–1.45)	75	22	3.36 (2.64–4.21)	61	65	0.93 (0.71–1.20)	92	92	1.00 (0.81–1.23)
Smoking-related cancers	1415	1170	1.21 (1.15–1.27)	449	148	3.03 (2.76–3.33)	400	430	0.93 (0.84–1.03)	566	592	0.96 (0.88–1.04)
Immune-related cancers	341	233	1.47 (1.32–1.63)	96	31	3.13 (2.53–3.82)	93	88	1.06 (0.86–1.30)	152	114	1.33 (1.13–1.56)
Alcohol-related cancers	1130	955	1.18 (1.12–1.25)	359	120	2.99 (2.69–3.32)	319	350	0.91 (0.82–1.02)	452	485	0.93 (0.85–1.02)
Obesity-related cancers	1487	1218	1.22 (1.16–1.28)	468	154	3.03 (2.76–3.32)	420	448	0.94 (0.85–1.03)	599	616	0.97 (0.90–1.05)

E, expected events; O, observed events; SIR, standardized incidence ratio.