Table 4.

Testosterone, sex hormone-binding globulin, free androgen index and hair testosterone at baseline and during treatment with a combined oral contraceptive or placebo.

	Baseline		P	Treatment		Pa
	COC (n = 97)	Placebo (n = 99)		COC (n = 76)	Placebo (n = 89)
Testosterone (nmol/L)	1.54 (1.22–2.10)	1.53 (1.25–2.00)	NS	1.37 (1.04–1.77)	1.67 (1.27–2.15)	0.002
SHBG	72 (47–104)	75 (54–99)	NS	103 (74–129)	62 (44–81)	0.000
Free androgen index	2.40 (1.39–4.04)	2.11 (1.39– 3.28)	NS	1.44 (0.95–2.08)	2.87 (1.80–4.57)	0.000
	(n = 90)	(n = 87)		(n = 75)	(n = 78)
Hair testosterone (pg/mg)	1.33 (1.02–1.92)	1.28 (0.95–1.69)	NS	1.26 (1.02–1.74)	1.41 (1.00–1.81)	NS

Data displayed as median (IQR).

^aSignificant P values have been calculated on delta values treatment – baseline, Mann–Whitney U test.

COC, combined oral contraceptive; NS, not significant; SHBG, sex hormone-binding globulin.