Table 3.

Chemokine receptors expression at the surface of peripheral immune T cells mirrors the melanoma metastatic dissemination.

Melanoma Stage	Tumor lesion localization	Chemokine receptors and integrins involved
Stage III	Regional cutaneous and lymph node metastases	Decrease of CCR6 and CXCR3 expressions on effector/memory peripheral T cells
Stage IV	Regional cutaneous and lymph node metastases + lung metastases	Reduction of CCR9, CXCR4, and CXCR5 expression on circulating T cells
Stage IV	Multi-disseminated disease with or without lung involvement	Increase expression of CCR10, CD103*, and CRTH2 on naïve peripheral T cells—Loss of CXCR3 and CCR6 expression on effector and memory circulating T cells—Decrease of CXCR4 and CCR9 expression on effector and terminal effector blood T cells

Chemokine receptors expression was retrospectively evaluated on circulating blood T cells collected from 57 stage III–IV melanoma patients (131–133).

^*Elevated expression of CD103 on naïve T cells is correlated with the presence of liver metastases.