Table 2.
Toxicity of treatment with docetaxel, nedaplatin, and 5‐fluorouracil in Japanese patients with resectable esophageal squamous cell carcinoma
| Toxicity grade (NCI‐CTC version 4.0) | Patients (n = 28) | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | All (%) | 3/4 (%) | |
| White blood cell decreased | 2 | 7 | 9 | 0 | 64.3 | 32.1 |
| Neutrophil count decreased | 2 | 6 | 5 | 6 | 67.9 | 39.3 |
| Febrile neutropenia | – | – | 3 | 0 | 10.7 | 10.7 |
| Anemia | 5 | 3 | 5 | 0 | 46.4 | 17.9 |
| Platelet count decreased | 5 | 1 | 3 | 0 | 28.6 | 10.7 |
| Anorexia | 4 | 7 | 9 | 0 | 71.4 | 32.1 |
| Fatigue | 7 | 6 | 1 | 0 | 50.0 | 3.6 |
| Fever | 1 | 0 | 0 | 0 | 3.6 | 0.0 |
| Nausea | 3 | 10 | 2 | 0 | 53.6 | 7.1 |
| Vomiting | 2 | 1 | 0 | 0 | 10.7 | 0.0 |
| Mucositis oral | 5 | 8 | 2 | 0 | 53.6 | 7.1 |
| Constipation | 4 | 1 | 0 | 0 | 17.9 | 0.0 |
| Diarrhea | 5 | 6 | 4 | 0 | 53.6 | 14.3 |
| Alopecia | 3 | 3 | 0 | 0 | 21.4 | 0.0 |
| Edema | 2 | 0 | 0 | 0 | 7.1 | 0.0 |
| Sensory neuropathy | 1 | 0 | 0 | 0 | 3.6 | 0.0 |
| AST increased | 6 | 0 | 0 | 0 | 21.4 | 0.0 |
| ALT increased | 9 | 0 | 0 | 0 | 32.1 | 0.0 |
| ALP increased | 0 | 1 | 0 | 0 | 3.6 | 0.0 |
| Hyponatremia | 3 | 0 | 1 | 0 | 14.3 | 3.6 |
| Creatinine increased | 2 | 1 | 0 | 0 | 10.7 | 0.0 |
| Skin hyperpigmentation | 2 | 0 | 0 | 0 | 7.1 | 0.0 |
–, a grade is not available. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CTC, Common Toxicity Criteria.