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. 2018 Oct 4;109(11):3494–3502. doi: 10.1111/cas.13790

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© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Immunostaining for laboratory of genetics and physiology 2 (LGP2) in human neuroblastoma (NB) tissues and patient survival. Representative pictures of immunostaining in NB tumors with various degrees of histological differentiation, including (A) undifferentiated neuroblastoma, (B) poorly differentiated neuroblastoma, (C) differentiated neuroblastoma and (D) ganglioneuroblastoma. Stronger cytoplasmic staining of LGP2 was found in ganglioneuroblastoma than in the other 3 histological types. Arrows indicate positive LGP2 staining. Original magnification, ×400. Scale bar, 50 μm. E, Kaplan‐Meier survival analysis in patients with NB according to LGP2 immunostaining. P‐value was calculated using a log‐rank test