Figure 8.

Resibufogenin (RB) inhibits Aspc xenograft tumor growth in nude mice as a single‐agent therapy. A, Mean body weight of RB‐treated mice measured at the indicated number of days. B‐D, Gross morphology of tumors, average xenograft tumor weight, and tumor volume were measured over 20 days (n = 6). E, Immunohistochemical staining was carried out for the determination of phosphorylated protein kinase C (p‐PKC)α/β, glycogen synthase kinase (p‐GSK)3β, and p‐p65 in mice tumor samples. Columns are expressed as mean ± SD of 6 samples in each group. *P < .05, **P < .005, ***P < .0005