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. 2018 Sep 22;109(11):3393–3402. doi: 10.1111/cas.13785

Table 1.

Relationship between milk fat globule‐epidermal growth factor factor 8 (MFG‐E8) expression and clinicopathological factors in 134 patients with esophageal squamous cell carcinoma

Patient characteristics Total MFG‐E8 low MFG‐E8 high P‐value
= 134 (%) n = 102 (%) n = 32 (%)
Age, years ≤65 73 (54.5) 52 (38.8) 21 (15.7) .15
>65 61 (45.5) 50 (37.3) 11 (8.2)
Sex Male 117 (87.3) 86 (64.2) 31 (23.1) .06
Female 17 (12.7) 16 (11.9) 1 (0.8)
Location[Link] Ut 18 (13.4) 10 (7.5) 8 (6.0) .028
Mt‐Lt 116 (86.6) 92 (68.7) 24 (17.9)
Tumor differentiation[Link] Well‐Mod 102 (76.1) 81 (60.5) 21 (15.7) .11
Por 32 (23.9) 21 (15.7) 11 (8.2)
Neoadjuvant chemotherapy With 68 (50.7) 41 (30.6) 27 (20.2) <.0001
Without 66 (49.3) 61 (45.5) 5 (3.7)
Tumor depth[Link] pT1‐2 47 (35.1) 37 (27.6) 10 (7.5) .6000
pT3‐4 87 (64.9) 65 (48.5) 22 (16.4)
Lymph node metastasis[Link] pN0‐1 83 (61.9) 69 (51.5) 14 (10.5) .0150
pN2‐3 51 (38.1) 33 (24.6) 18 (13.4)
Non‐regional lymph node metastasis[Link] pM0 111 (82.8) 91 (67.9) 20 (14.9) .0005
pM1 23 (17.2) 11 (8.2) 12 (9.0)
Tumor stage[Link] I‐II 51 (38.0) 42 (31.3) 9 (6.7) .1800
III‐IV 83 (62.0) 60 (44.8) 23 (17.2)

Upper (Ut), middle (Mt), and lower (Lt) third of thorax.

Well, moderately (Mod), and poorly (Por) differentiated squamous cell carcinoma.

Pathological classification according to UICC (7th edition).